The Protective Effect of Recombinant Human Erythropoietin against Cisplatin-Induced Ototoxicity

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The Protective Effect of Recombinant Human Erythropoietin against Cisplatin-Induced Ototoxicity

Department of Otorhinolaryngology, Dokuz Eylul University School of Medicine, İzmir, Turkey (ED, YO, GK, EAG) Department of Laboratory of Animal Science, Dokuz Eylul University School of Medicine, İzmir, Turkey (EK, OY) Department of Basic Oncology, Dokuz Eylul University School of Medicine, İzmir, Turkey (PE, SA, ZA) Department of Biostatistics, Dokuz Eylul University School of Medicine, İzmir...

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Re: Sex differences in protective effect of recombinant human erythropoietin against cisplatin-induced nephrotoxicity in rats.

INTRODUCTION The protective role of recombinant human erythropoietin (RHE) against cisplatin-induced nephrotoxicity has been reported, but the role of sex differences is not clearly known. The aim of this study was to determine the sex-based difference in the protective effect of RHE against cisplatin-induced nephrotoxicity. MATERIALS AND METHODS Thirty-three Wistar rats were divided into 6 g...

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Protective Effect of Tempol against Cisplatin-Induced Ototoxicity

One of the major adverse effects of cisplatin chemotherapy is hearing loss. Cisplatin-induced ototoxicity hampers treatment because it often necessitates dose reduction, which decreases cisplatin efficacy. This study was performed to investigate the effect of Tempol on cisplatin-induced ototoxicity in an auditory cell line, House Ear Institute-Organ of Corti 1 (HEI-OC1). Cultured HEI-OC1 cells ...

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The Protective Effect of Cortexin on Cisplatin-Induced Ototoxicity.

OBJECTIVE The aim of this report is to evaluate whether cortexin provides any protective activity against ototoxicity of cisplatin. MATERIALS AND METHODS The study was performed on 30 healthy adult Wistar Albino rats, and rats were randomly divided into three groups of ten. Group I (Control group) was given intraperitoneal (ip) saline solution 1 mL/day. Group II (Cisplatin group) was given ip...

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ژورنال

عنوان ژورنال: The Journal of International Advanced Otology

سال: 2015

ISSN: 1308-7649,2148-3817

DOI: 10.5152/iao.2014.361